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Cosco et al., 2016)

Thus, diet that is well-planned and contains sufficient amounts of these nutrients is one of the means through which L-carnitine production can be sustained

In addition, xCT expression can be regulated by the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/PKB/mTOR) 29,30,31 and mitogen-activated protein kinase (MAPK) pathways in synergy with activating transcription factor 4 (ATF4), which is activated by endoplasmic reticulum stress

At the gastric level, it slows gastric emptying and reduces both postprandial glucose excursions and gastric acid secretion

So far, six patients with clEDS and tissue fragility have been reported in the literature, predominantly but not exclusively of the gastrointestinal tract: (1) perforation of colonic diverticulum, development of multiple abscesses requiring partial colectomy, complicated by second small bowel perforation in a 36-year-old man