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16 weeks 1-2 x 10 mL bottles ~3-6 mL used across reta + MOTS-c reconstitutions

b FIGARO trial in progress which will give further information on use of MRA in HF and ASCVD

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In DURATION-8 (exenatide once weekly plus dapagliflozin once daily vs exenatide or dapagliflozin alone in patients with T2D inadequately controlled with metformin monotherapy), 11 AWARD-10 (dulaglutide as an add-on therapy to SGLT2 inhibitors in patients with inadequately controlled T2D), 12 and SUSTAIN 9 (semaglutide once weekly as an add-on to SGLT-2 inhibitor therapy in T2D), 13 the combination of a GLP-1 RA with an SGLT2 inhibitor led to additional reductions in HbA 1c , weight, and blood pressure

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