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For widespread eczema covering large body surface areas, systemic delivery (subcutaneous injection) ensures all affected areas receive benefit without the impracticality of applying topical preparations everywhere

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J Biol Chem 291:68136830 Gaillard PJ, Kerklaan BM, Aftimos P, Altintas S, Jager A, Gladdines W, Lonnqvist F, Soetekouw P, Verheul H, Awada A et al (2014) Abstract CT216: Phase I dose escalating study of 2B3-101, glutathione PEGylated liposomal doxorubicin, in patients with solid tumors and brain metastases or recurrent malignant glioma

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