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The 46 hour offset balances NAD+ availability with receptor readiness
Also when you take B12 as a sublingual tablet or chewable form, it will usually contain sugar alcohols like xylitol etc
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Your clinical team will discuss the specific laboratory markers and next steps during your first consultation
The optimal dosing sequence is 5-Amino-1MQ first (50100mg fasted), followed by MOTS-c 46 hours later (510mg), allowing NAD+ replenishment before increased mitochondrial demand
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