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Presenting symptoms for irAEs can be nonspecific and at times subtle making them difficult to be identified
Patients might experience nausea, vomiting and even diarrhea
In addition, our results suggest a novel mechanism involving low GSH-associated AMPK activation that prevents alcohol-induced steatosis, which challenges the existing knowledge on the role of low GSH in alcoholic liver disease
Thus, the effects in H727 cells and GOT-1 cells were less pronounced compared to results obtained with BON-1 cells
Mustacich D (2001)
It is synthesized primarily in the liver, though individual cells can help regulate their own intracellular glutathione levels based on metabolic need
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