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When compared to Phentermine, Semaglutide demonstrated significant associations with lower oculomotor binocular dysfunction (HR 0.42, 95% CI: 0.270.66, p = 1 10 4 ), dry eye disease (HR 0.61, 95% CI: 0.380.99, p = 0.044), ametropic accommodative dysfunction (HR 0.44, 95% CI: 0.280.70, p = 3.1 10 4 ), and visual disturbances (HR 0.71, 95% CI: 0.510.98, p = 0.038), while cataracts (HR 0.56, 95% CI: 0.311.00, p = 0.047) and visual issues and blindness (HR 0.77, 95% CI: 0.571.06, p = 0.105) showed borderline or non-significant associations