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In the simulation of F347, the ligand adopts the same orientation as in the crystal structure, whereas the orientation of the ligand in the simulation of C347 is varied during the simulation process (the trifluoromethyl-pyrazole group in particular)

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Keskin E, Ekmekci S, Oztekin O, Diniz G

it alters how the body processes food and fat

The topical route has the broadest applicability and the longest cosmetic safety record