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There are many reasons, though the primary factors are likely: the addictive nature of many ultra processed foods that override our hunger signaling pathways, the higher calorie/lower nutrient qualities of these foods, the reduced intake of dietary fiber, our sedentary lifestyles, and the influence of antibiotics and other microbiome-disrupting chemicals in our food supply

GIP (glucose-dependent insulinotropic polypeptide) is another incretin-related hormone with roles in nutrient handling and energy metabolism

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Newer diabetes drugs do not increase fetal risk Newer diabetes medicines do not appear to increase the risk of birth defects