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This included a reduction in RAGE protein expression, suppression of key inflammatory cytokines (IL-6, IL-12, TNF-), and attenuation of matrix-degrading enzymes [9]

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The proposed involvement of SLC6A14 could be tested in animal models by assessing the transport of carnitine across the blood brain barrier and testing for abnormalities resulting from brain carnitine deficiency, Beaudet said

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Other potentially serious adverse events linked to the use of the drug include acute gallstone disease and thyroid neoplasm

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