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Gastrointestinal side effects such as nausea, vomiting, and diarrhea are the most commonly reported but typically improve over time

Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-B, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages

Critically, these effects were absent in 3-AR knockout mice, indicating that an intact 3-AR pathway is required for the lipolytic activity

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BPC-157 appears better suited for systemic and deep tissue applications, particularly gastrointestinal protection, musculoskeletal repair, and neuroprotection, where its multi-pathway mechanism of action addresses complex healing processes