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Several compounds from garlic , including ajoene (Hattori 2001), diallyl disulfide (Zhao 1998), S-allylmercaptocysteine (Sumioka 2001), and fresh garlic homogenates (Wang 1996) have been shown to preserve liver glutathione levels as well as reduce serum markers of liver damage, liver tissue death, and animal mortality in rodent models of acetaminophen overdose when supplied in sufficient quantities (up to 5 g/kg for fresh garlic homogenates)
TB500 has been evaluated in animal models, typically at doses of 250500 mcg per injection or 6 mg/kg body weight , administered multiple times weekly
Notably, the highest dose tested (54 mg) showed increased gastrointestinal event frequency compared to lower doses, suggesting a dose-relationship for this effect category
Alpha class of GSTs, which is expressed in most tissues, including brain 45 , is specific for its substrate promiscuity as a consequence of protein flexibility and dynamics in the enzymes active site 46
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