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Their use for PCOS represents off-label prescribing, which requires specialist assessment, clinical justification, and informed patient consent

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Resveratrol, a natural activator of SIRT1, can deacetylate and activate key transcription factors, reducing oxidative stress and promoting mitophagy (Table 2)

These wont replace training or substitute for GLP-1 in Charleston, but they can support adherence and results, especially for those with sedentary lifestyles or physical limitations

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