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In particular, studies showing diminished 24-hour melatonin levels or disrupted melatonin rhythm - where the primary endogenous melatonin release fails to synchronize with the dark phase of the daily light-dark cycle - have been correlated with an elevated risk of AD

Nature 517 , 455459 (2015)

In a one-year randomized trial in older adults, a walking program increased anterior hippocampal volume by about 2 percent, while the same region shrank by about 1.4 percent in the control group, against a normal loss of 1 to 2 percent a year at this age

(DHFR = dihydrofolate reductase

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