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no Phase II or III trials published Most common AOD-9604 side effect / Injection-site reaction (redness, swelling) Most common reported MOTS-c side effect / Transient flushing and mild GI discomfort (anecdotal, not trial-confirmed) Growth hormone axis impact / AOD-9604 does not activate the GH receptor

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Homocysteine accumulates in the blood when there is inadequate folate and/or vitamin B 12 for effective functioning of the methionine synthase enzyme (see Function)

Linear standard curves enabled detection of both compounds sensitively in the low fmol range (Fig