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Serious side effects are rare but can include pancreatitis, gallbladder disease, kidney issues, or thyroid tumors

Regulatory guidance still recommends stopping the drug if pancreatitis is suspected, but theres no strong evidence of a direct link

These data point to some degree of refractoriness in the metabolic responses to this insulin sensitizer in our models, which could be consistently overcome by the treatment with GLP1/E, even at low-to-moderate doses

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