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Tanigawa, T

Nutritional and hormonal regulation of glutathione homeostasis

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and centralnervous system cell death in vitro 15

doi: 10.1038/nature08530 184 FurusawaYObataYFukudaSEndoTANakatoGTakahashiDet al

A., Dobson, R