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Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis and inflammation in individuals with obesity and prediabetes: a randomized controlled trial

Many members use GLP-1s for 312 months, then transition to lifestyle-based maintenance supported by continued Healthspan coaching and monitoring

To view or add a comment, sign in Albuterol (Salbutamol) Class: Short-acting beta-2 adrenergic receptor agonist (SABA) Bronchodilator Mechanism of Action Stimulates beta-2 adrenergic receptors in bronchial smooth muscle Increases cAMP activates protein kinase A relaxation of smooth muscle bronchodilation Uses Acute relief of bronchospasm in: Asthma Chronic obstructive pulmonary disease (COPD) Exercise-induced bronchoconstriction (EIB) Hyperkalemia (off-label: shifts potassium into cells temporarily) Routes of Administration Inhalation (preferred): Metered-dose inhaler (MDI), nebulizer Oral: Tablets or syrup (less preferred due to systemic effects) IV: Rarely, in severe status asthmaticus Dosage (Typical) Inhalation (adults/children 4 years): 90180 mcg (12 puffs) every 46 hours as needed Nebulizer: 2.5 mg every 20 minutes 3 doses, then 2.5 mg every 24 hours as needed Adverse Effects Tremors (most common) Tachycardia, palpitations Nervousness, headache Hypokalemia (especially with high doses) Rare: arrhythmias, paradoxical bronchospasm Precautions / Contraindications Use caution in patients with cardiac disease, arrhythmias, hypertension Avoid overuse tolerance and decreased effectiveness Monitor for hypokalemia in severe asthma exacerbations SABA = rescue inhaler for acute asthma symptoms Quick onset (~5 minutes), short duration (~46 hours) Side effects: tremor and tachycardia Can be used temporarily in hyperkalemia to shift K into cells First-line therapy for acute bronchospasm To view or add a comment, sign in Im Excited to share our new open-access review in Diabetes, Obesity & Metabolism: Diabetic kidney disease, biomarkers, and finerenone. Why this matters: Diabetic kidney disease (DKD) affects ~3040% of people with diabetes and remains the leading cause of kidney failure worldwide, tightly linked to cardiovascular risk

We believe San Diego is a great community to build and grow a high-tech infrastructure and technology company because of the incredible workforcethe ability to attract top talent and draw from world-class universities. Startup honoree La Jolla Labs is tackling one of medicines biggest challenges by developing personalized RNA therapeutics for patients with rare diseasesmany of them children with neurological disorders like ALS