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Sun Y, Bai YP, Wang DG, Xing YJ, Zhang T, Wang W, et al

Reed, J

Excessive production of ROS, largely arising from mitochondrial oxidative phosphorylation, is a major driver of oxidative damage and mitochondrial dysfunction processes that correlate with MDD symptom severity, illness chronicity, cognitive impairment, and poor antidepressant response [138, 139]

Acute toxicity manifests within days to weeks after ingesting a few very high doses, typically more than 100 times the recommended dietary allowance (RDA)