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While the HHS Secretarys aggressive recent announcement strongly signals an imminent return to legal, regulated 503A compounding for these substances in the United Stateswhich would drastically improve product safety and puritythey currently remain illegal to compound, investigational, and totally unapproved
Intrinsic Factor and Absorption Challenges As previously noted, intrinsic factor is a key player in B12 absorption, as it binds to the vitamin, allowing for proper absorption
Endocrinology 164:115 Leenders F, Groen N, de Graaf N, Engelse MA, Rabelink TJ, de Koning EJP, Carlotti F (2021) Oxidative stress leads to -cell dysfunction through loss of -cell identity
The oxidized form (GSSG) is essentially "spent" and must be recycled by the body using energy before it can become useful again
There are no clinical studies on compounded tirzepatide + B12 that prove these benefits
Proc Natl Acad Sci USA
