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This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models

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3dg and 3os (vehicle n = 8 mice, 100 nmol kg 1 MK-801 n = 8 mice, 100 nmol kg 1 GLP-1 n = 8 mice, 100 nmol kg 1 GLP-1MK-801 n = 8 mice)

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Dosing: Common protocols involve 5-10 mg daily for 10-20 days, repeated several times per year