Retatrutide Retatrutide works differently to Ozempic because it has a triple-action mechanism , targeting the GLP-1, GIP, and glucagon receptors
The FDA-approved dosing schedule for tirzepatide allows for escalation from 2.5 mg to a maximum of 15 mg weekly, with increases of 2.5 mg at minimum four-week intervals based on clinical response and tolerability
Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years
Be patient with yourself and stay consistent with your dietary and lifestyle changes
Life 16 , 11651169 (2023)
it's about what makes the dosing protocol for your specific research practical and accurate