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Most people lead with Retatrutide so the body adjusts to the dominant compound, then add Cagrilintide once that rhythm is comfortable
Therefore, they share the same half-life of approximately seven days
The 15 mg dose reached 11.2 kg at the same time point
Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively
In real-world practice, patients who experience severe gastrointestinal side effects may adjust their behavior more freely, drinking more fluids, reducing doses, or taking breaks
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