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Since semaglutide slows gastric emptying, certain foodslike those high in fat or sugarcan sit in your stomach for longer, leading to uncomfortable feelings of nausea, bloating, or heartburn

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4 Clinical evidence In adults with obesity, 72 weeks of orforglipron treatment resulted in greater body-weight reductions than placebo, up to -11.2%, compared to -2.1% with placebo

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It can lead to death, which is why patients are typically asked to fast before surgery

These medicines are prescribed alongside dietary changes, physical activity and long-term lifestyle support