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Although direct interconnections between the release of pro-inflammatory cytokines and S accumulation have yet to be established, altered pro-inflammatory cells in experimental PD models suggest that inflammation and S dysregulation are closely interconnected (Tan et al., 2020)

While the rapid calorie restriction drives weight loss, it can also lead to nutritional deficiencies, muscle loss, and metabolic adaptation that makes weight regain more likely after stopping

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The underlying mechanisms of cardiovascular and renal protection differ partially between GLP1-RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (primarily systemic and intrarenal hemodynamic changes)

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