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Mixing them creates stability and degradation issues that compromise the efficacy of both compounds

This misunderstanding leads to either excessive dosing or under-dosing

Animal studies suggest that bardoxolone has a narrow therapeutic window because its metabolites could also be toxic

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When demand outpaces production, levels drop

The osmolarity is 0.This preparation is designed solely for parenteral use only after addition to drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection.Sterile Water for Injection contains no bacteriostatic, antimicrobial agent or added buffer and is supplied only in single dose containers to dilute or dissolve drugs for injection.For IV injection, add sufficient amount to a solute to make an approximately isotonic solution