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Neither approach is inherently better - they serve different budgets, different medical situations, and different risk tolerances - but they shouldn't be evaluated as substitutes for one another

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Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials

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On the other hand, the simultaneous presence of both Arg244 and Lys240 leads to a less readily accessible active site, especially when considering the flexible nature of both residues, which leads to the shape of the active site pocket changing with the oscillation frequency of Arg244 and Lys240