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doi:10.1038/s42255-023-00917-5

, Biochem Pharmacol 147:141-152 , USA , 2018 Diet-induced obese mice lost approximately 5.1% body weight and 35% fat mass, with adipocyte size reduced by more than 30% and lower plasma cholesterol - all without changes in food intake or overt adverse effects

Of further importance is the well-known effect of exercise in IGF-1 plasma level rise

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These results are in line with a recent study showing that the main effect of low, non-toxic and pharmacologically relevant concentration of 2-DG was to increase the incorporation of mannose on the glycan structure instead of inhibiting glycosylation 26