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Oral GLP-1s for obesity saw a recent setback when in April (April 2025), Pfizer announced that it was discontinuing development of danuglipron, an oral GLP-1 receptor agonist, which was being investigated for chronic weight management, due to potential liver toxicity
The weight loss caused by CagriSema was substatntial with more than half of patients losing 15 Percentage or more of weight at 32 weeks [10]
Incretin-like drugs mimic these hormones, and while we do not have any head-to-head trials, you can see from the informative Figure below, summarizing best results of this family of drugs to date, moving from single agonist GLP-1 to double and then triple (GLP-1-GIP-GCG), there is incremental body weight loss
At the 9mg dose, 8.8% of participants experienced dysesthesia
FDA, on February 3, 2012 Healthy People Co
Barchas, J
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