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Symptoms include a change in urine colour or difficulty urinating and lower abdomen or back pain

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Compounds and standards were captured by a biotinylated monoclonal anti-human IgG1 antibody at 100 g/mL (in-house) and detected by an Alexa-labelled monoclonal anti-human IgG1 antibody at 10 nM (The Binding Site) on a Gyrolab Bioaffy 200 CD platform (Gyros AB)

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This article reviews the clinical efficacy and tolerability of afamelanotide in EPP and summarizes its pharmacological properties