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The neuroprotective action of metformin may be mediated by the phosphorylation of specific amino acid residues (Lysine) of the glutamate transporters (GLAST and GLT-1), since metformin activated the PKC signaling and promoted cascades of phosphorylation in p38 MAPK and Akt proteins

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The animal evidence is consistent with the mechanistic findings

Mechanically activated integrin switch controls 51 function