3rd generation glp 1 Comment “Curious” for the deep dive. Retatrutide — a.k.a. “Reta” or “GLP-3” — is being called a future “trillion-dollar drug” and a revolution in fat loss. Retatrutide is a third-generation GLP-1–based drug. ( Retatrutide - The Third Generation

Moreover, the long-term effects of therapeutic GIP receptor antagonism in humans are not fully elucidated and are thought to depend on the specific drug molecule, receptor functions, and the extent of GLP-1 receptor activation

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Its also approved for weight management at higher doses under the brand name Wegovy

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The SURMOUNT-5 trial directly compared the two medications and found tirzepatide produced approximately 20 percent weight loss compared to 14 percent for semaglutide