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A clinically significant subset of subjects developed impaired fasting glucose or frank glucose intolerance, particularly those with pre-existing insulin resistance
For severe cases or when conservative measures fail, surgical options may become necessary
The FDA's 503A framework does not require the same pharmacokinetic studies as NDA approval, so hepatic-impairment data will not come from a manufacturer
, 42 MOTS-c 1 ,
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The shRNA sequences are listed in Table 1
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