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rather, they induce the assembly of the NLRP3 inflammasome, further amplifying the cascading release of IL-1 and IL-18, thereby constructing a self-amplifying pro-inflammatoryoxidative positive feedback loop
It can also make it harder to know which medicine is causing a new symptom
Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China ORCID: Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Email: [email protected] ORCID: Explor Neuroprot Ther
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Upon ferroptosis induction, Grx2 becomes activated by disassembly of the FeS-cluster introducing the FeS-cluster bound in Grx2 dimers as a ferroptosis sensor
