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PK and PD analysis The PK of AMG 133 was evaluated using a validated liquid-chromatography tandem mass spectrometry (LCMS/MS) methodology to detect total AMG 133, defined as the GIPR-Ab with or without the GLP-1 analogue peptides and intact AMG 133, defined as the GIPR-Ab with at least one attached GLP-1 analogue peptide

Versus biomimetic cosmetic peptides (matrixyl, argireline, acetyl hexapeptide): these peptides are protein fragments with targeted activity (calcium neurotransmission modulation for argireline, matrix stimulation for matrixyl)

Mitchell PD, Salter BM, Oliveria JP, et al

2021;35(11):e774-e776

Reduced Hyperpigmentation and Sunspots Sun exposure is one of the primary causes of hyperpigmentation, sunspots, and uneven skin tone

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