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Effect of the combined compound probiotics with mycotoxindegradation enzyme on detoxifying aflatoxin B1 and Zearalenone
HepG2 cells were purchased from ECACC and were cultured in Minimum Essential Medium supplemented with 10% FBS and 1% non-essential amino acids (Invitrogen)
Shortly after the drug was released, it was aggressively marketed by Novo Nordisk and quickly became popular for its ability to help with weight loss, which was considered an off-label use
This high cost, along with limited manufacturing supply, means usage has remained mostly concentrated in wealthier countries (notably the US and parts of Europe) and among patients who can afford to pay
Given these complexities, the use of GLP-1 RAs in adolescents should be reserved for those with severe obesity or those who have not responded adequately to lifestyle interventions
PMID 17982477
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