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& Herrmann, W
3,5 Due to comorbidities such as CKD, insulin may inadvertently become the preferred agent of choice in patients with gastroparesis and T2DM
Mechanistically, TMAO disrupts myocardial calcium homeostasis through two distinct pathways: direct elevation of intracellular Ca 2+ concentration and promotion of SERCA2a (sarco/endoplasmic reticulum Ca 2+ -ATPase) autophagic degradation, which attenuates sarcoplasmic reticulum Ca 2+ reuptake capacity (Lei et al., 2025)
The tissues were fixed in 4% paraformaldehyde and then embedded in paraffin
These microbiota-derived agents can inhibit Gram-negative pathogens through diverse mechanisms, such as direct bactericidal activity, modulation of host immune responses, and promotion of colonization resistance
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