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YLC, BGO, SS, NMJ and HC contributed to the writing of the main manuscript text, and YLC prepared Figures 18 and Tables 1, 2

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Bias between mini-G s and -arrestin-2 recruitment was determined similarly to earlier work (Pickford et al ., 2020), by subtracting the log /K values (Kenakin et al ., 2012) for each ligand in each pathway for each assay to determine log /K A (referred to here as LogR)

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