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Calcineurin inhibitors CsA use is associated with a dose-dependent increase in total cholesterol and low-density lipoprotein (LDL) cholesterol, a decrease in high-density lipoprotein (HDL) cholesterol, and an increase in serum triglycerides (202, 203)
Moreover, vitamin C increases synthesis and secretion of melanin 175 and by the improvement of antioxidant defense capacity of melanocytes significantly contributes to melanogenesis prevention 46
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Reid M et al
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The concentrations were calculated by a calibration curve made with mannan (0-1000 mg/L) and the results were expressed as mg/109 cells
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