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Specifically, MPC1 upregulation restricts lactate production and the subsequent lactylation of FASN at lysine 673, hindering FASN activity and resulting in lipid deposition in the liver tissue of patients and mice with NAFLD

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doi:10.1093/bioinformatics/btt285 Tamayo-Trujillo R, Ruiz-Pozo VA, Cadena-Ullauri S, et al

Kolodziejczyk J, Saluk-Juszczak J, Wachowicz B, Elsevier (2011) L-Carnitine protects plasma components against oxidative alterations

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Model predictions fitted accurately with observed trough profiles for post-dose fasting time, water volume, renal impairment and hepatic impairment (Fig