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Adverse events were less frequent with dapagliflozin than placebo (56% vs 64%), and no serious adverse events were reported in the dapagliflozin group [32]

GLP-1s are approved for people with a BMI of 27 or higher who have a weight-related condition like high cholesterol, or a BMI of 30 or above

This is important considering the shared risk factors, particularly elevated blood pressure, dyslipidaemia and obesity, for developing CVD and T2DM

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The authors would also like to thank SYSBIO/ISBE.IT Center of Systems Biology, particularly Professor Lilia Alberghina, and the Project of Excellence CHRONOS (CHRonical multifactorial disorders explored by NOvel integrated Strategies) of the Department of Biotechnology and Biosciences, University of Milano-Bicocca, for providing advanced technologies used in this study