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Zepbound's evidence comes from SURMOUNT-1, also published in NEJM (Jastreboff et al., 2022)

This suggests that semaglutide may be significantly more effective in addressing the vascular and metabolic contributions to cognitive impairment and dementia (VCID) than the specific amyloid- and tau-driven pathology of AD

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Side effects are common and can be significant, including muscle loss, nausea, and gastrointestinal issues

45 Identifying Optimal Candidates for GLP-1RA Therapy in Heart Failure The selection of patients with HF for GLP-1RA therapy requires careful consideration of the HF phenotype, comorbidities and available evidence

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