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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]
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Immune cells are particularly sensitive to oxidative stress because of their high percentage of polyunsaturated fatty acids in the plasma membranes, along with naturally producing more oxidative products