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The protocol page gives the basic cycle answer, while this page covers timeline planning in more detail

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This is intramuscular injections and given into arms or buttocks areas

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Some signs of B12 deficiency in chickens include: Leg weakness Nervous system impairment Perosis Poor feathering Reduced hatch rates (from deficient parents embryos frequently die at around 17 days old) Most commercial chicken feed contains B vitamins, so B12 deficiency is less common

The dose simply not working An incorrect dose, or one that mostly landed in fat, may mean your symptoms do not improve as expected