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The findings of the rapid and long-lasting antidepressant effects of LAC (which increases the expression of mGlu2, inhibitor of spontaneous glutamate release) supports the idea that targeting the glutamate system can lead to rapid antidepressant effects in agreement with the prior discovery of the antidepressant action of ketamine [48,49,50]

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Big questions remain, she added

Donatoni da Silva, L., Shiel, A., Sheahan, J., & McIntosh, C