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As with headache, distinguishing treatment-related fatigue from background symptoms in obese populations with potential sleep disorders presents methodological challenges
The compound failed its Phase IIb obesity endpoint in 2007, and Metabolic Pharmaceuticals terminated clinical development the same year
intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention
Regular lab monitoring is critical to managing B12 levels effectively, especially for those with ongoing deficiencies
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Vitamin B12 deficiency (E53.8): Documented by laboratory values
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