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Further optimization led to semaglutide analogue A747 (with mutations L23B R, I20B Q, V24B R, and R25B A) which exhibits nine interfacial salt bridges, compared to two in native semaglutide

Dapagliflozin-treated patients had a lower incidence of these events 6.6% vs

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All peptides were provided by the Novo Nordisk Research Center Indianapolis, and have been previously validated in vitro and in vivo for receptor specificity and their ability to decrease body weight in DIO mice 13,14,15,22,41

These events occurred at similar rates in placebo groups, suggesting they may not be directly attributable to the peptide