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(2000) study in adult female rats demonstrated that Ipamorelin administration increased bone mineral content and periosteal bone formation markers without the concurrent cortisol and prolactin elevations observed with other GHRPs, providing early evidence that Ipamorelin's selective GH elevation could drive anabolic skeletal effects through a cleaner endocrine profile

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New England Journal of Medicine , 387 (3), 205216

Levels of GHK-Cu decline with age, and cosmetic professionals have incorporated it into topical regimens to help promote a more youthful, revitalized look