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The p62-Keap1-Nrf2 pathway can be activated by ferroptosis inducers, promoting the transcription of heme oxygenase-1 ( HMOX1 ), FTH1 and quinone oxidoreductase-1( NQO1 ) (164, 166)

18 , while the study by Rahbar et al

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(B) HepG2 cells, transfected with 50 nM AMPK, SIRT6, or scrambled (Scr) small interfering RNA (siRNA) for 24 hours, were treated with 400 M PA, followed by treatment with or without 100 nM exendin-4 and liraglutide for 24 hours