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This pathway mainly regulates ferroptosis by inducing and activating the expression of SREBP1, which can target and activate the downstream SCD1, and SCD1 can inhibit cell ferroptosis by increasing the content of MUFA
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Moreover, the recent evidences suggest that the isozymes of seleno-GPx may contribute differently to tissue-specific radioresistance
That has led to the fear that these agents might promote malignancies
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