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For the tumour allograft model, Gclc f/f Rosa26 creERT2 MMTV-PYMT mice were euthanized and autochthonous tumours were collected, cut into 8 mm 3 fragments and cryopreserved in liquid nitrogen

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That compared with a 2.1% weight loss, or less than 5 pounds, in patients who received a placebo

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